John Roth (geneticist)

John R. Roth

John R. Roth
Born March 14, 1939 (1939-03-14) (age 73)
Winona, Minnesota
Nationality American
Fields Genetics
Institutions University of California, Berkeley
University of Utah
University of California, Davis
Alma mater Harvard University (BA)
Johns Hopkins University (PhD)
Umea University (PhD Honoris Causa)]]
Doctoral advisor Phil Hartman
Notable awards Thomas Hunt Morgan Medal (Genetics Society of America) (2009)[1]
Spouse Shery G. Roth

John R. Roth[2] is a Distinguished Professor of Biological Sciences at the University of California, Davis. He became known for his early studies on the structure and regulation of the his operon of Salmonella[3], and went on to investigate regulation in systems as diverse as suppression by tRNA[4], NAD biosynthesis[5], and the Vitamin B12-dependent metabolism of small molecules such as ethanolamine and propanediol[6]. In collaboration with David Botstein and Nancy Kleckner, he developed the use of transposons as genetic tools[7]. As a by-product of his study of transposons, he developed an interest in chromosomal duplications, which are frequent in bacteria.[8] He has recently authored several papers on the involvement of such small-effect mutations on evolution under selection. [9] In 1988, he became a member of the National Academy of Sciences[10], and in 2009 was awarded the Thomas Hunt Morgan Medal of the Genetics Society of America. [1]

References

  1. ^ a b Thomas Hunt Morgan Medal
  2. ^ Maloy, S., Hughes, K.T. & Casadesus, J., ed (2011). The Lure of Bacterial Genetics: A Tribute to John Roth. Washington, DC: ASM Press. pp. 362. ISBN 978-1-55581-538-7. 
  3. ^ Johnston, M., Barnes, W., Chumley, F., Bossi, L. & Roth, J.R. (1980). "Model for regulation of the histidine operon of Salmonella". Proc.Natl.Acad.Sci. USA 77: 508–512. 
  4. ^ Hartman, P. & Roth, J.R. (1973). "Mechanisms of suppression". Adv.Genet. 17: 1–105. 
  5. ^ Zhu, N. & Roth, J.R. (1991). "The nadI region of Salmonella typhimurium encodes a bifunctional regulatory protein". J.Bacteriol. 173: 1302–1310. 
  6. ^ Roof, D.M. & Roth, J.R. (1992). "Autogenous regulation of ethanolamine utilization by a transcriptional activator of the eut operon in Salmonella typhimurium". J.Bacteriol. 174: 6634–6643. 
  7. ^ Kleckner, N., Botstein, D. & Roth, J.R. (1977). "Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics". J.Mol.Biol. 116: 125–159. 
  8. ^ Roth, J.R., Benson, N., Galitski, T., Haack, K., Lawrence, J. & Miesel, L. (1996). "Rearrangements of the bacterial chromosome: formation and applications". In Neidhardt, F.C., Curtis, R., III, Ingraham, J.L., Lin, E.C.C., Low, K.B., Magasanik, B., Reznikoff, W.S., Riley, M., Schaechter, M. & Umbarger, H.E.. Escherichia coli and Salmonella: Cellular and Molecular Biology. Washington, DC: ASM Press. pp. 2256–2276. ISBN 1555810845. 
  9. ^ Andersson, D.I., Hughes, D. & Roth, J.R. (2011). "The origin of mutants under selection: interactions of mutation, growth, and selection, Chapter 5.6.6". In Finkel, S.. EcoSal -- Escherichia coli and Salmonella: Cellular and Molecular Biology. 10.1128. Washington, DC: ASM Press. http://www.ecosal.org. PDF
  10. ^ Members' Directory